Pharmacologic Substance
diflunisal
[ dih-floo-nuh-sal ]
Effect:
Decreased Prostaglandin Production
May Treat:
Arthritis, Rheumatoid; Osteoarthritis; Pain
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to diflunisal:
  • A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life.
    NCI
    U.S. National Cancer Institute, 2021
  • A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.