Pharmacologic Substance
dimesna
[ dy-mez-nuh ]
Definitions related to dimesna:
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A drug that belongs to the family of drugs called chemoprotective agents.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic derivative of dithio-ethane sulfonate with uroprotective properties. In the kidney, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis.NCI ThesaurusU.S. National Cancer Institute, 2021
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