Immunologic Factor
dinutuximab Audio
[ din-yoo-tuk-sih-mab ]
Brand Names:
Unituxin
Effect:
Increased Cellular Death; Increased Immunologic Activity
May Treat:
Neuroblastoma
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to dinutuximab:
  • A chimeric mouse/human monoclonal antibody with potential antineoplastic activity. Dinutuximab binds to the ganglioside GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells. GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small cell carcinoma of the lung.
    NCI
    U.S. National Cancer Institute, 2021
  • A substance being studied in the treatment of cancer. It binds to a molecule called GD2, which is found in greater than normal amounts on some types of cancer cells. This helps cells of the immune system kill the cancer cells. It is a type of monoclonal antibody.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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