Pharmacologic Substance
ditiocarb
Subclass of:
Thiocarbamates
Definitions related to ditiocarb:
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A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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