Pharmacologic Substance
docetaxel
[ doh-seh-tak-sil ]
Brand Names:
Docefrez; Taxotere
Effect:
Decreased DNA Integrity; Decreased Meiosis; Decreased Mitosis; Decreased Protein Synthesis; Decreased RNA Integrity; Microtubule Inhibition
May Treat:
Breast Neoplasms;
Carcinoma, Non-Small-Cell Lung;
Head and Neck Neoplasms;
Melanoma;
Ovarian Neoplasms;
Pancreatic Neoplasms;
Prostatic Neoplasms;
Soft Tissue Neoplasms;
Stomach Neoplasms
More Information:
Definitions related to docetaxel:
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A drug used together with other drugs to treat certain types of breast cancer, stomach cancer, prostate cancer, and certain types of head and neck cancer. It is also being studied in the treatment of other types of cancer. Docetaxel is a type of mitotic inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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