Pharmacologic Substance
donepezil Audio
[ doh-neh-peh-zil ]
Brand Names:
Aricept; Namzaric
Effect:
Increased Central Nervous System Acetylcholine Activity
May Treat:
Alzheimer Disease
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to donepezil:
  • A drug that is used to treat Alzheimer disease and is being studied in the treatment of side effects caused by radiation therapy to the brain. It is a type of cholinesterase inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases.
    NCI
    U.S. National Cancer Institute, 2021
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