Pharmacologic Substance
doxazosin
Brand Names:
Cardura
Effect:
Arterial Vasodilation; Decreased Bladder Sphincter Tone; Decreased Blood Pressure; Venous Vasodilation
May Treat:
Hypertension; Prostatic Hyperplasia; Urinary Retention
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to doxazosin:
  • A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A quinazoline with antihypertensive and antineoplastic properties. Doxazosin is an alpha-adrenergic antagonist that selectively inhibits alpha-1 adrenergic receptors. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. This agent also shows high affinity to alpha-1c adrenoceptor, the predominant functional type in the prostate, which may partially attribute to its effect in treatment of benign prostatic hyperplasia. Furthermore, doxazosin induces apoptosis in prostate cancer cells mediated through inhibition of protein kinase B (PKB)/Akt-signaling death receptor regulatory pathway.
    NCI
    U.S. National Cancer Institute, 2021
  • Medication used to treat high blood pressure or an enlarged prostate gland.
    Harvard Dictionary of Health Terms
    Harvard Medical Publishing, 2011
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.