Antibiotic
doxorubicin hydrochloride Audio
dox·o·ru·bi·cin hy·dro·chlo·ride [ dok-soh-roo-bih-sin hy-droh-klor-ide ]
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Breast Neoplasms; Gastrointestinal Neoplasms; Hodgkin Disease; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Mesothelioma; Multiple Myeloma; Neuroblastoma; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Soft Tissue Neoplasms; Testicular Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Wilms Tumor
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to doxorubicin hydrochloride:
  • A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin PFS comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
    NCI
    U.S. National Cancer Institute, 2021
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.