Finding
drug tolerance
drug tol·er·ance [ druhg tol-er-uhns ]
Subclass of:
Pharmacological Phenomena
Definitions related to drug tolerance:
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A condition that occurs when the body gets used to a medicine so that either more medicine is needed or different medicine is needed.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A reduction in the sensitivity to a drug following its repeated administration, in which increased doses are required to produce the same magnitude of effect previously produced by a smaller dose. This increase in dose may be necessitated by changes in the metabolism of the drug, or a cellular, physiological or behavioral adaptation to the effects of the drug.NCI ThesaurusU.S. National Cancer Institute, 2021
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Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Tendency of a drug, with repeated use, to become less effective (i.e., require higher dosage) or associated with user dependence; do not use for lack of adverse reactions, as in "the subject tolerated the drug well".CRISP ThesaurusNational Institutes of Health, 2006
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