Antibiotic
duocarmycins
Subclass of:
Pyrroles;
Indoles
Definitions related to duocarmycins:
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A group of pyrroloindole compounds often with additional spirocyclic unit(s) and their analogs originally isolated from STREPTOMYCES. They bind DNA minor grooves with adenine-N3 alkylation activity.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(duocarmycin antineoplastic antibiotic) A spirocyclopropylhexadienone-containing antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. Duocarmycin antibiotics alkylate DNA by binding to adenine-thymine (A-T)- rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.NCI ThesaurusU.S. National Cancer Institute, 2021
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