Pharmacologic Substance
eflornithine
Brand Names:
Vaniqa
Effect:
Cellular Growth Phase Alteration; Decreased DNA Replication; Decreased Protein Synthesis; Decreased RNA Replication
May Treat:
Hypertrichosis; Trypanosomiasis, African
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to eflornithine:
  • A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • (difluoromethylornithine) Polyamine antagonist which reversibly inhibits DNA polymerase and irreversibly inhibits ornithine decarboxylase; used against bladder cancer, with potential applications in epilepsy and PCP withdrawal.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Eflornithine, drug used to treat late-stage African trypanosomiasis (sleeping sickness). Eflornithine is effective only against Trypanosoma brucei gambiense, which causes Gambian (or West African) sleeping sickness. It is not effective against T. brucei rhodesiense, which causes Rhodesian (or East...
    Encyclopedia Britannica
    Encyclopedia Britannica, Inc., 2020
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.