Pharmacologic Substance
epirubicin
Brand Names:
Ellence
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Breast Neoplasms
More Information:
Definitions related to epirubicin:
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A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.NCI ThesaurusU.S. National Cancer Institute, 2021
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A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Epirubicin is a type of anthracycline antibiotic.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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