Pharmacologic Substance
epirubicin hydrochloride Audio
[ eh-pih-roo-bih-sin hy-droh-klor-ide ]
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Breast Neoplasms
More Information:
ChemID; DailyMed; DrugInfo; PDR
Definitions related to epirubicin hydrochloride:
  • A drug used together with other drugs to treat early breast cancer that has spread to lymph nodes. It is also being studied in the treatment of other types of cancer. Ellence is a type of anthracycline antibiotic.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.