Pharmacologic Substance
eplerenone
Brand Names:
Inspra
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Decreased Distal Tubule H+ Excretion; Decreased Distal Tubule K+ Excretion; Increased Distal Tubule Na+ Excretion
May Treat:
Heart Failure, Systolic; Hypertension
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to eplerenone:
  • A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.