Pharmacologic Substance
eplerenone
Brand Names:
Inspra
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Decreased Distal Tubule H+ Excretion; Decreased Distal Tubule K+ Excretion; Increased Distal Tubule Na+ Excretion
May Treat:
Heart Failure, Systolic;
Hypertension
More Information:
Definitions related to eplerenone:
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A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure.NCI ThesaurusU.S. National Cancer Institute, 2021
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A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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