Pharmacologic Substance
eszopiclone
Brand Names:
Lunesta
Effect:
Gamma Amino Butyric Acid (GABA) Activity Alteration
May Treat:
Sleep Initiation and Maintenance Disorders
More Information:
Definitions related to eszopiclone:
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A nonbenzodiazepine, cyclopyrrolone and active stereoisomer of zopiclone with hypnotic and sedative activity and without significant anxiolytic activity. Although the exact mechanism of action remains to be fully elucidated, eszopiclone is able to bind to and activate the omega-1 subtype of the alpha subunit of the gamma-aminobutyric acid-benzodiazepine GABA receptor complex (GABA-A), a chloride ionophore complex in the central nervous system (CNS). This leads to the opening of chloride channels, causing hyperpolarization, inhibition of neuronal firing, and enhancement of the inhibitory effect of GABA. This eventually leads to a hypnotic effect and allows for an induction of sleep.NCI ThesaurusU.S. National Cancer Institute, 2021
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A pyridine, pyrazine, and piperazine derivative that is used as a HYPNOTIC AND SEDATIVE in the treatment of INSOMNIA.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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