Pharmacologic Substance
ethacrynic acid
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Increased Loop of Henle Ca++ Excretion; Increased Loop of Henle Cl- Excretion; Increased Loop of Henle K+ Excretion; Increased Loop of Henle Mg++ Excretion; Increased Loop of Henle Na+ Excretion
May Treat:
Acute Kidney Injury;
Ascites;
Edema;
Heart Failure;
Hypertension;
Kidney Failure, Chronic;
Liver Cirrhosis;
Nephrotic Syndrome;
Pulmonary Edema
More Information:
Definitions related to ethacrynic acid:
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A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An unsaturated ketone derivative of aryloxyacetic acid without a sulfonamide substituent belonging to the class of loop diuretics. Ethacrynic acid is extensively bound to plasma proteins; both ethacrynic acid in its unchanged form as well as its metabolites are excreted in bile and urine.NCI ThesaurusU.S. National Cancer Institute, 2021
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