Pharmacologic Substance
ethynodiol diacetate
Effect:
Decreased Placental Human Chorionic Gonadotropin Secretion; Hypothalamic Endocrine Activity Alteration
May Prevent:
Pregnancy
May Treat:
Endometriosis; Hypogonadism
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to ethynodiol diacetate:
  • A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL).
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • The diacetate salt form of ethynodiol, a semi-synthetic progestational hormone agonist. Ethynodiol diacetate binds to cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. In addition, ethynodiol diacetate has weak oestrogenic and androgenic properties.
    NCI
    U.S. National Cancer Institute, 2021
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