Pharmacologic Substance
felbamate
Brand Names:
Felbatol
Effect:
Decreased Disorganized Electrical Activity; Decreased Organized Electrical Activity
May Treat:
Epilepsy, Complex Partial;
Lennox Gastaut Syndrome;
Seizures
More Information:
Definitions related to felbamate:
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A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A propanediol compound with anticonvulsant and antiepileptic properties. Although the exact mechanism of action is unknown, Felbamate may be an antagonist at the strychnine-insensitive glycine-recognition site of the N-methyl-D-aspartate (NMDA) receptor-ionophore complex, thereby blocking the effects of the excitatory amino acids, suppressing neuronal firing, and preventing seizure activity. Felbamate also has weak inhibitory effects on gamma-aminobutyric acid (GABA) receptor binding sites which may contribute to its inhibitory effect on neuronal excitatory.NCI ThesaurusU.S. National Cancer Institute, 2021
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