Pharmacologic Substance
flavopiridol
[ flah-voh-pih-rih-dol ]
Definitions related to flavopiridol:
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(alvocidib) The free base form of a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.NCI ThesaurusU.S. National Cancer Institute, 2021
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Antineoplastic cyclin dependent kinase inhibitor.CRISP ThesaurusNational Institutes of Health, 2006
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