Pharmacologic Substance
flavoxate
Effect:
Decreased Smooth Muscle Nerve Growth Factor Activity
May Treat:
Dysuria;
Nocturia;
Urinary Incontinence
More Information:
Definitions related to flavoxate:
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A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic parasympatholytic with antimuscarinic, muscle relaxant and urinary antispasmodic properties. Flavoxate binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. In addition, this agent has been found to inhibit cyclic AMP formation in striatal membranes of the brain through stimulation of pertussis toxin-sensitive G protein-coupled receptors which in turn suppress isovolumetric urinary bladder contraction.NCI ThesaurusU.S. National Cancer Institute, 2021
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