Pharmacologic Substance
fluocinonide
Brand Names:
Vanos
Effect:
Antipruritic Activity; Decreased Immunologically Active Molecule Activity; Decreased Protein Synthesis; Vasoconstriction
May Treat:
Facial Dermatoses; Foot Dermatoses; Hand Dermatoses; Inflammation; Leg Dermatoses; Pruritus; Scalp Dermatoses
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to fluocinonide:
  • A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activities. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.
    NCI
    U.S. National Cancer Institute, 2021
  • A topical glucocorticoid used in the treatment of ECZEMA.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.