Pharmacologic Substance
fluphenazine hydrochloride Audio
[ floo-feh-nuh-zeen hy-droh-klor-ide ]
Effect:
Decreased Dopamine Activity; Decreased Histamine Activity; Decreased Norepinephrine Activity; Decreased Serotonin Activity; Hypothalamic Endocrine Activity Alteration
May Treat:
Psychotic Disorders; Schizophrenia
More Information:
ChemID; DailyMed; PDR
Definitions related to fluphenazine hydrochloride:
  • A drug that is used to treat mental and emotional disorders and is being studied in the treatment of multiple myeloma. Fluphenazine hydrochloride may stop tumor growth by keeping myeloma cells from dividing and causing them to die. It is a type of antipsychotic.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2 receptors in the limbic system, cortical system and basal ganglia, resulting in a reduction of schizophrenia-associated hallucinations and delusions. In addition, as a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin.
    NCI
    U.S. National Cancer Institute, 2021
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