Pharmacologic Substance
fotemustine Audio
[ foh-teh-mus-teen ]
Definitions related to fotemustine:
  • A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.
    NCI
    U.S. National Cancer Institute, 2021
  • A substance being studied in the treatment of brain tumors and metastatic melanoma of the eye. It is a type of nitrosourea.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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