Disease or Syndrome
frontotemporal dementia
Subclass of:
Frontotemporal Lobar Degeneration
Definitions related to frontotemporal dementia:
  • A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2025
  • A syndrome caused by progressive degeneration of the frontal or temporal lobes of the brain. It is manifested with personality changes and deterioration of the language skills.
    NCI
    U.S. National Cancer Institute, 2021
  • The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Frontotemporal dementia (FTD) refers to sporadic and hereditary disorders that affect the frontal and temporal lobes, including Pick disease.
    Merck Manuals
    Merck & Co., Inc., 2025
  • Frontotemporal dementia is an umbrella term for a group of uncommon brain disorders that primarily affect the frontal and temporal lobes of the brain. These areas of the brain are generally associated with personality, behavior and language.
    Mayo Clinic
    Mayo Foundation for Medical Education and Research, 2025
  • Frontotemporal dementias (FTDs) are a group of neurodegenerative disorders associated with shrinking of the frontal and temporal anterior lobes of the brain. Symptoms include marked changes in social behavior and personality, and/or problems with language. People with behavior changes may have disinhibition (with socially inappropriate...
    NIH Genetic and Rare Diseases
    National Center for Advancing Translational Sciences
  • Frontotemporal dementias (FTDs) are the second most frequent primary neurodegenerative brain diseases (after Alzheimer disease) in adults <65 years of age. The FTD spectrum comprises a heterogeneous group of conditions that appear heritable in some cases. Prominent early symptoms include progressive coarsening of personality, social...
    Epocrates
    Athenahealth, Inc., 2019
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