Pharmacologic Substance
fulvestrant
[ ful-ves-trunt ]
Brand Names:
Faslodex
Effect:
Decreased Ovarian Estrogen Secretion
May Treat:
Breast Neoplasms
More Information:
Definitions related to fulvestrant:
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A drug used to treat certain types of breast cancer in postmenopausal women. It is also being studied in the treatment of other types of cancer. Faslodex blocks estrogen activity in the body and is a type of antiestrogen.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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