Antibiotic
geldanamycin analogue
Definitions related to geldanamycin analogue:
  • (geldanamycin analog) An antineoplastic antibiotic drug that belongs to the family of drugs called ansamycins.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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