Pharmacologic Substance
gemfibrozil
Brand Names:
Lopid
Effect:
Increased Lipolysis
May Prevent:
Coronary Artery Disease
May Treat:
Coronary Artery Disease;
Hypercholesterolemia;
Hyperlipoproteinemias;
Hypertriglyceridemia
More Information:
Definitions related to gemfibrozil:
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A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).NCI ThesaurusU.S. National Cancer Institute, 2021
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A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Lipid regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.CRISP ThesaurusNational Institutes of Health, 2006
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