Enzyme
glucarpidase
[ gloo-kar-pih-dayz ]
Brand Names:
Voraxaze
May Treat:
Drug-Related Side Effects and Adverse Reactions
More Information:
Definitions related to glucarpidase:
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A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor.NCI ThesaurusU.S. National Cancer Institute, 2021
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(carboxypeptidase-g2) A bacterial enzyme that breaks down proteins and other substances, including methotrexate. It is being studied in the treatment of toxic effects caused by methotrexate. It may also help activate certain drugs to kill cancer cells. It is a type of chemoprotective agent and a type of prodrug activator.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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