Pharmacologic Substance
gossypol
gos·sy·pol [ gos-uh-pawl, -pol ]
Subclass of:
Sesquiterpenes
Definitions related to gossypol:
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A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A substance being studied in the treatment of several types of cancer. It comes from the seed of the cotton plant (Gossypium). It blocks the growth of cells and may kill cancer cells. Cottonseed meal toxin may also act as a male contraceptive (a type of birth control).NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An orally-active polyphenolic aldehyde with potential antineoplastic activity. Derived primarily from unrefined cottonseed oil, gossypol induces cell cycle arrest at the G0/G1 phase, thereby inhibiting DNA replication and inducing apoptosis. This agent also inhibits cell-signaling enzymes, resulting in inhibition of cell growth, and may act as a male contraceptive.NCI ThesaurusU.S. National Cancer Institute, 2021
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