Enzyme
granzyme
Definitions related to granzymes:
  • A family of serine endopeptidases. Members of this family are stored in the granules of cytotoxic T cells. Upon release of the granules, these enzymes enter infected cells where they can proteolytically stimulate caspase activation and initiate apoptosis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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