Pharmacologic Substance
halofuginone hydrobromide
[ ha-loh-fyoo-jih-none hy-droh-broh-mide ]
Definitions related to halofuginone hydrobromide:
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A substance that is being studied for its ability to slow the growth of connective tissue and to prevent the growth of new blood vessels that tumors need to grow. It is a type of quinazolinone alkaloid and a type of antiangiogenesis agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.NCI ThesaurusU.S. National Cancer Institute, 2021
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