Biologically Active Substance
hemoglobin S
Subclass of:
Abnormal Hemoglobins
Definitions related to hemoglobin, sickle:
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(hemoglobin s) A tetrameric complex of 2 molecules of hemoglobin subunit alpha (encoded by either the HBA1 or HBA2 gene) and 2 molecules of a hemoglobin subunit beta variant where the glutamic acid residue at position 7 has been replaced by valine.NCI ThesaurusU.S. National Cancer Institute, 2021
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(hemoglobin s) Abnormal hemoglobin caused by a point mutation in the beta chains, found in sickle cell anemia.CRISP ThesaurusNational Institutes of Health, 2006
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An abnormal hemoglobin assay is a device consisting of the reagents, apparatus, instrumentation, and controls necessary to isolate and identify abnormal genetically determined hemoglobin types.Standard Product NomenclatureU.S Food & Drug Administration, 2003
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An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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