Biologically Active Substance
hemoglobin S
Subclass of:
Abnormal Hemoglobins
Definitions related to hemoglobin, sickle:
  • (hemoglobin s) A tetrameric complex of 2 molecules of hemoglobin subunit alpha (encoded by either the HBA1 or HBA2 gene) and 2 molecules of a hemoglobin subunit beta variant where the glutamic acid residue at position 7 has been replaced by valine.
    NCI
    U.S. National Cancer Institute, 2021
  • (hemoglobin s) Abnormal hemoglobin caused by a point mutation in the beta chains, found in sickle cell anemia.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • An abnormal hemoglobin assay is a device consisting of the reagents, apparatus, instrumentation, and controls necessary to isolate and identify abnormal genetically determined hemoglobin types.
    Standard Product Nomenclature
    U.S Food & Drug Administration, 2003
  • An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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