• A syndrome characterized by progressive kidney failure in a patient with cirrhosis or fulminant liver failure.
  NCI
  U.S. National Cancer Institute, 2021
• Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. It is characterized by intense renal vasculature constriction, reduced renal blood flow, OLIGURIA, and sodium retention.
  NLM Medical Subject Headings
  U.S. National Library of Medicine, 2025
• Hepatorenal syndrome (HRS) is the development of renal failure in patients with advanced chronic liver disease, occasionally fulminant hepatitis, who have portal hypertension and ascites. Estimates indicate that at least 40% of patients with cirrhosis and ascites will develop HRS during the natural history of their disease.
  Medscape
  WebMD, 2025
• Hepatorenal syndrome is a form of impaired kidney function that occurs in individuals with advanced chronic liver disease. As many as 40% of individuals with cirrhosis and ascites will develop hepatorenal syndrome. Symptoms may include fatigue, abdominal pain, and a general feeling of ill health (malaise). There are two distinct types of...
  NIH Genetic and Rare Diseases
  National Center for Advancing Translational Sciences
• Hepatorenal syndrome (HRS) is the development of renal failure in patients with severe liver disease (acute or chronic) in the absence of any other identifiable cause of renal pathology.
  Epocrates
  Athenahealth, Inc., 2019