Pharmacologic Substance
hirudins
Subclass of:
Antithrombin Proteins
Definitions related to hirudins:
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Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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