Gene or Genome
homeobox gene
[ hoh-mee-uh-boks ]
Subclass of:
Genes, Developmental
Definitions related to genes, homeobox:
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(homeobox gene) A family of genes that contain a highly conserved sequence of approximately 180 nucleotides, which encode an approximately 60 amino acid helix-turn-helix DNA binding domain made up of 2 antiparallel alpha helices and one nearly perpendicular alpha helix connected by short chains of unstructured amino acid sequences. This gene family is involved in transcriptional regulation during embryonic development.NCI ThesaurusU.S. National Cancer Institute, 2021
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(homeobox gene) Genes that code for DNA binding genetic regulatory proteins in a variety of organisms, so named for the homeotic genes of Drosophila.CRISP ThesaurusNational Institutes of Health, 2006
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Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Homeotic gene, any of a group of genes that control the pattern of body formation during early embryonic development of organisms. These genes encode proteins called transcription factors that direct cells to form various parts of the body. A homeotic protein can activate one gene but repress...Encyclopedia Britannica, Inc., 2020
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