Genetic Function
homologous recombination
ho·mol·o·gous re·com·bi·na·tion
Subclass of:
Recombination, Genetic
Definitions related to homologous recombination:
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An exchange of DNA between matching or similar sequences.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The process of exchange of genetic material between autonomous replicons, which depends on regions of extensive sequence homology between the participating DNA strands. This process involves double-strand breakage of one participant, resection of the break, and strand invasion, followed by formation, displacement and resolution of the Holliday junction. This process is involved in repairing broken DNA and creating combinations of genes that may be unique from the parent duplexes. Disruptions in this process can result in inviability, premature aging and predisposition to cancers and degenerative diseases.NCI ThesaurusU.S. National Cancer Institute, 2021
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Homologous recombination, the exchange of genetic material between two strands of DNA that contain long stretches of similar base sequences. Homologous recombination occurs naturally in eukaryotic organisms, bacteria, and certain viruses and is a powerful tool in genetic engineering. In eukaryotes...Encyclopedia Britannica, Inc., 2020
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