Pharmacologic Substance
hydralazine
[ hahy-dral-uh-zeen ]
Brand Names:
Bidil
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Decreased Vascular Smooth Muscle Tone
May Treat:
Heart Failure;
Hypertension, Malignant;
Hypertension, Pulmonary
More Information:
Definitions related to hydralazine:
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A direct-acting vasodilator that is used as an antihypertensive agent.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A phthalazine derivative with antihypertensive effects. Hydralazine exerts its vasodilatory effects through modification of the contractile state of arterial vascular smooth muscle by altering intracellular calcium release, and interfering with smooth muscle cell calcium influx. This agent also causes inhibition of phosphorylation of myosin protein or chelation of trace metals required for smooth muscle contraction, thereby resulting in an increase in heart rate, stroke volume and cardiac output.NCI ThesaurusU.S. National Cancer Institute, 2021
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Direct-acting vasodilator that is used as an antihypertensive.CRISP ThesaurusNational Institutes of Health, 2006
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