Pharmacologic Substance
hydralazine
[ hahy-dral-uh-zeen ]
Brand Names:
Bidil
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Decreased Vascular Smooth Muscle Tone
May Treat:
Heart Failure; Hypertension, Malignant; Hypertension, Pulmonary
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to hydralazine:
  • A direct-acting vasodilator that is used as an antihypertensive agent.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A phthalazine derivative with antihypertensive effects. Hydralazine exerts its vasodilatory effects through modification of the contractile state of arterial vascular smooth muscle by altering intracellular calcium release, and interfering with smooth muscle cell calcium influx. This agent also causes inhibition of phosphorylation of myosin protein or chelation of trace metals required for smooth muscle contraction, thereby resulting in an increase in heart rate, stroke volume and cardiac output.
    NCI
    U.S. National Cancer Institute, 2021
  • Direct-acting vasodilator that is used as an antihypertensive.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.