Pharmacologic Substance
hydroxyurea Audio
[ hahy-drok-see-yoo-ree-uh, -yoo r-ee-uh ]
Brand Names:
Droxia; Hydrea; Siklos
Effect:
Decreased DNA Integrity
May Treat:
Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Hypereosinophilic Syndrome; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukocytosis; Melanoma; Ovarian Neoplasms; Polycythemia Vera; Prostatic Neoplasms; Psoriasis; Thrombocythemia, Essential; Uterine Neoplasms
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to hydroxyurea:
  • A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An anticancer drug that belongs to the family of drugs called antimetabolites.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Ribonucleotide reductase inhibitor which thereby lowers intracellular dNTP pools and slows DNA replication and repair; used as antineoplastic, cell devision inhibitor, and possible chemotherapy for sickle cell anemia.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.