Pathologic Function
hyperpigmentation
hy·per·pig·men·ta·tion
Subclass of:
Pigmentation Disorders
Definitions related to hyperpigmentation:
  • Abnormal darkening of the skin.
    NICHD Pediatric Terminology
    U.S. National Cancer Institute, 2021
  • Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • (skin hyperpigmentation) Darkening of the skin due to excessive melanin deposition. Causes include skin injuries, pregnancy, eczema, and Addison disease.
    NCI
    U.S. National Cancer Institute, 2021
  • (hyperpigmentation of the skin) A darkening of the skin related to an increase in melanin production and deposition.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2025
  • (skin hyperpigmentation) A disorder characterized by darkening of the skin due to excessive melanin deposition.
    Common Terminology Criteria for Adverse Events
    U.S. National Institutes of Health, 2021
  • Hyperpigmentation has multiple causes and may be focal or diffuse. Most cases are due to an increase in melanin production and deposition.
    Merck Manuals
    Merck & Co., Inc., 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.