Disease or Syndrome
hypersplenism
[ hahy-per-splee-niz-uhm, -splen-iz- ]
Subclass of:
Splenic Diseases
Definitions related to hypersplenism:
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A malfunctioning of the spleen in which it prematurely destroys red blood cells.Human Phenotype Ontology (HPO)The Human Phenotype Ontology Project, 2021
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Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Overactive functioning of the spleen, resulting in excessive destruction of blood cells.NCI ThesaurusU.S. National Cancer Institute, 2021
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Hypersplenism is cytopenia caused by splenomegaly. Hypersplenism is a secondary process that can arise from splenomegaly of almost any cause. Splenomegaly increases the spleen�s mechanical filtering and destruction of red blood cells (RBCs) and often of white blood cells (WBCs) and platelets. Compensatory bone marrow hyperplasia occurs...Merck & Co., Inc., 2020
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