Disease or Syndrome
hypersplenism
[ hahy-per-splee-niz-uhm, -splen-iz- ]
Subclass of:
Splenic Diseases
Definitions related to hypersplenism:
  • A malfunctioning of the spleen in which it prematurely destroys red blood cells.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2021
  • Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Overactive functioning of the spleen, resulting in excessive destruction of blood cells.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Hypersplenism is cytopenia caused by splenomegaly. Hypersplenism is a secondary process that can arise from splenomegaly of almost any cause. Splenomegaly increases the spleen�s mechanical filtering and destruction of red blood cells (RBCs) and often of white blood cells (WBCs) and platelets. Compensatory bone marrow hyperplasia occurs...
    Merck Manuals
    Merck & Co., Inc., 2020
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.