Pharmacologic Substance
inamrinone
Effect:
Positive Chronotropy; Positive Inotropy; Pulmonary Arterial Vasodilation; Pulmonary Venous Vasodilation; Systemic Arterial Vasodilation; Systemic Venous Vasodilation; Vasodilation
May Treat:
Cardiac Output, Low; Cardiomyopathy, Dilated; Heart Failure; Shock, Cardiogenic
Definitions related to inamrinone:
  • (amrinone) A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic bipyridine phosphodiesterase inhibitor with inotropic and vasodilator properties. Inamrinone inhibits type III phosphodiesterase, which is abundant in cardiac and vascular tissues, thereby preventing the degradation of cyclic adenosine monophosphate (cAMP) and increasing intracellular concentrations of this secondary messenger. Elevated levels of cAMP increase the contractile force of the cardiac muscle and produce positive inotropic effects. Although the mechanism of action is not fully understood, inamrinone causes smooth muscle relaxation, resulting in peripheral vasodilation (reduced afterload) and a decreased pulmonary vascular resistance (reduced preload).
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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