Pharmacologic Substance
irbesartan
Brand Names:
Avalide; Avapro
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Treat:
Diabetic Nephropathies; Hypertension; Ventricular Dysfunction, Left
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to irbesartan:
  • A nonpeptide angiotensin II antagonist with antihypertensive activity. Irbesartan selectively and competitively blocks the binding of angiotensin II to the angiotensin I receptor. Angiotensin II stimulates aldosterone synthesis and secretion by adrenal cortex, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. (NCI05)
    NCI
    U.S. National Cancer Institute, 2021
  • A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Antihypertensive; nonpeptide angiotension 1 subtype; angiotension 2 receptor antagonist.
    CRISP Thesaurus
    National Institutes of Health, 2006
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