Neoplastic Process
juvenile xanthogranuloma
Subclass of:
Histiocytosis, Non-Langerhans-Cell;
Dermatologic disorders
Definitions related to juvenile xanthogranuloma:
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A benign histiocytic tumor that occurs during childhood; it is distinct from Langerhans cell histiocytosis. It is characterized by the presence of lipid-laden, foamy histiocytes and Touton-type giant cells in the dermis. The lesions usually develop during infancy. They consist of cutaneous papules and nodules (most often in the head and neck). It is sometimes associated with deep soft tissues nodules.NCI ThesaurusU.S. National Cancer Institute, 2021
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A macrophage disorder that occurs during childhood; it is distinct from Langerhans cell histiocytosis, and is characterized by cutaneous papules and nodules (most often in the head and neck).NICHD Pediatric TerminologyU.S. National Cancer Institute, 2021
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Juvenile xanthogranuloma is the most common type of non-Langerhans cell histiocytosis characterized by the occurrence of one or more reddish or yellowish self-limiting and benign papules or nodules of several millimeters in diameter, usually appearing on the head and neck (but sometimes on the extremities and trunk) during the first year of life (or rarely in adulthood) and usually regressing spontaneously. Extracutaneous involvement has also been reported, involving most commonly the eye (uveal tract) but with other locations including the central nervous system, lung, liver, bones and endocrine glands, and may be associated with considerable morbidity.OrphaNetINSERM, 2021
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(xanthogranuloma, juvenile) Benign disorder of infants and children caused by proliferation of HISTIOCYTES, macrophages found in tissues. These histiocytes, usually lipid-laden non-Langerhans cells, form multiple yellow-red nodules most often in the skin, the eye, and sometimes in the viscera. Patients appear to have normal lipid metabolism and are classified as a normolipemic non-Langerhans cell histiocytosis.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Juvenile xanthogranuloma (JXG) primarily is a self-limited dermatologic disorder that is associated rarely with systemic manifestations. Infants and small children are mainly affected.WebMD, 2019
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