Pharmacologic Substance
lamivudine Audio
[ luh-mih-vyoo-deen ]
Brand Names:
Cimduo; Combivir; Delstrigo; Dovato; Epivir; Epivir HBV; Epzicom; Symfi; Temixys; Triumeq; Trizivir
Effect:
Decreased Reverse Transcription to DNA; Increased Immunologically Active Molecule Activity
May Treat:
Acquired Immunodeficiency Syndrome
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to lamivudine:
  • A drug used to treat infection caused by viruses.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.