Pharmacologic Substance
lithium carbonate
lith·i·um car·bon·ate
Brand Names:
Lithobid
Effect:
Norepinephrine Activity Alteration; Serotonin Activity Alteration
May Treat:
Bipolar Disorder; Conduct Disorder; Depressive Disorder; Stress Disorders, Post-Traumatic
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to lithium carbonate:
  • A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells.
    NCI
    U.S. National Cancer Institute, 2021
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