Pharmacologic Substance
mafosfamide Audio
[ muh-fos-fuh-mide ]
Definitions related to mafosfamide:
  • A form of cyclophosphamide that can be administered as an intrathecal infusion. Mafosfamide is being studied as an anticancer drug. It belongs to the family of drugs called alkylating agents.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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