Immunologic Factor
mapatumumab Audio
[ ma-puh-too-moo-mab ]
Definitions related to mapatumumab:
  • A fully human agonistic monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) with apoptosis promoting and potential antitumor activities. TRAIL-R1 is a cell surface receptor expressed on many malignant cell types. Mapatumumab selectively binds to and activates the TRAIL cell receptor, thereby inducing apoptosis and reducing tumor growth.
    NCI
    U.S. National Cancer Institute, 2021
  • (anti-trail r1-mab) A substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL R1 on the surface of some tumor cells. This may kill the tumor cells. Anti-TRAIL R1-mAb is a type of monoclonal antibody.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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