Pharmacologic Substance
methazolamide
Effect:
Decreased Intraocular Fluid Pressure; Increased Proximal Tubule Cl- Excretion; Increased Proximal Tubule HCO3- Excretion; Increased Proximal Tubule K+ Excretion; Increased Proximal Tubule Na+ Excretion
May Treat:
Glaucoma, Angle-Closure; Glaucoma, Open-Angle
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to methazolamide:
  • A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A sulfonamide derivate and carbonic anhydrase inhibitor with potential antineoplastic activity. Methazolamide inhibits tumor-associated carbonic anhydrase IX (CAIX), which may result in increased cell death in hypoxic tumors. As a hypoxia-inducible transmembrane glycoprotein, CAIX catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, helping to maintain acidification of the tumor microenvironment and enhance resistance to cytotoxic therapy in some hypoxic tumors.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.