Pharmacologic Substance
methocarbamol
[ meth-uh-kahr-buh-mawl, -mol ]
Brand Names:
Robaxin
Effect:
Centrally-mediated Muscle Relaxation; Decreased CNS Organized Electrical Activity; Striated Muscle Metabolic Alteration
May Treat:
Muscle Cramp; Muscle Rigidity; Myositis; Pain; Spasm; Tetanus
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to methocarbamol:
  • A carbamate with centrally acting muscle relaxant properties. Though the exact mechanism of action of methocarbamol was not established, it's postulated to be via a mechanism similar of carbamate, inhibition of acetylcholinesterase at synapses in the autonomic nervous system, neuromuscular junction, and central nervous system. Methocarbamol has no direct effect on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
    NCI
    U.S. National Cancer Institute, 2021
  • A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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